Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome☆
Identifieur interne : 001216 ( Pmc/Checkpoint ); précédent : 001215; suivant : 001217Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome☆
Auteurs : Jia-Ling Huang [République populaire de Chine] ; Jian Huang [République populaire de Chine] ; Zhao-Hui Duan [République populaire de Chine] ; Jing Wei [République populaire de Chine] ; Jun Min [République populaire de Chine] ; Xiao-Hong Luo [République populaire de Chine] ; Jian-Guo Li [République populaire de Chine] ; Wei-Ping Tan [République populaire de Chine] ; Li-Zhi Wu [République populaire de Chine] ; Ran-Yi Liu [République populaire de Chine] ; Yan Li [République populaire de Chine] ; Jing Shao [République populaire de Chine] ; Bi-Jun Huang [République populaire de Chine] ; Yi-Xin Zeng [République populaire de Chine] ; Wenlin Huang [République populaire de Chine]Source :
- Microbes and Infection [ 1286-4579 ] ; 2005.
Abstract
The immune spectrum of severe acute respiratory syndrome (SARS) is poorly understood.
To define the dynamics of the immune spectrum in SARS, serum levels of cytokines, chemokines, immunoglobulins, complement and specific antibodies against SARS-associated coronavirus (SARS-CoV) were assayed by enzyme-linked immunosorbent assay (ELISA), and phenotypes of peripheral lymphocytes were analyzed by flow cytometry in 95 SARS-infected patients. Results showed that interleukin (IL)-10 and transforming growth factor β (TGF-β) were continuously up-regulated during the entirety of SARS. Regulated on activation normally T cell-expressed and secreted (RANTES) levels were decreased, while monocyte chemoattractant protein-1 (MCP-1) was elevated in acute patients. Immunoglobulins and complement were elevated during the first month of SARS. Both serum-positive rates and titers of specific IgM and IgG antibodies responding to SARS-CoV peaked at days 41–60 from the onset of SARS. CD4+ and CD8+ T lymphocytes decreased significantly in acute-phase. CD3+CD8+CD45RO+ T lymphocytes were decreased by 36.78% in the convalescent patients. Conclusion: SARS-CoV seemed to elicit effective humoral immunity but inhibited cellular immunity, especially CD8+ memory T lymphocytes over time. Prolonged overproduction of IL-10 and TGF-β may play an important role in the disease.
Url:
DOI: 10.1016/j.micinf.2004.11.017
PubMed: 15784184
PubMed Central: 7110803
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:7110803Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome<sup><xref ref-type="fn" rid="d32e1261">☆</xref></sup></title><author><name sortKey="Huang, Jia Ling" sort="Huang, Jia Ling" uniqKey="Huang J" first="Jia-Ling" last="Huang">Jia-Ling Huang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Huang, Jian" sort="Huang, Jian" uniqKey="Huang J" first="Jian" last="Huang">Jian Huang</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of General Surgery, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of General Surgery, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020</wicri:regionArea><wicri:noRegion>Guanzhou 510020</wicri:noRegion></affiliation></author><author><name sortKey="Duan, Zhao Hui" sort="Duan, Zhao Hui" uniqKey="Duan Z" first="Zhao-Hui" last="Duan">Zhao-Hui Duan</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Clinical Test, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Test, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020</wicri:regionArea><wicri:noRegion>Guanzhou 510020</wicri:noRegion></affiliation></author><author><name sortKey="Wei, Jing" sort="Wei, Jing" uniqKey="Wei J" first="Jing" last="Wei">Jing Wei</name><affiliation wicri:level="1"><nlm:aff id="aff4">Medical Research Center, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical Research Center, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020</wicri:regionArea><wicri:noRegion>Guanzhou 510020</wicri:noRegion></affiliation></author><author><name sortKey="Min, Jun" sort="Min, Jun" uniqKey="Min J" first="Jun" last="Min">Jun Min</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of General Surgery, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of General Surgery, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020</wicri:regionArea><wicri:noRegion>Guanzhou 510020</wicri:noRegion></affiliation></author><author><name sortKey="Luo, Xiao Hong" sort="Luo, Xiao Hong" uniqKey="Luo X" first="Xiao-Hong" last="Luo">Xiao-Hong Luo</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Clinical Test, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Test, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020</wicri:regionArea><wicri:noRegion>Guanzhou 510020</wicri:noRegion></affiliation></author><author><name sortKey="Li, Jian Guo" sort="Li, Jian Guo" uniqKey="Li J" first="Jian-Guo" last="Li">Jian-Guo Li</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Respiratory Disease, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory Disease, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020</wicri:regionArea><wicri:noRegion>Guanzhou 510020</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Wei Ping" sort="Tan, Wei Ping" uniqKey="Tan W" first="Wei-Ping" last="Tan">Wei-Ping Tan</name><affiliation wicri:level="1"><nlm:aff id="aff6">Department of Pediatrics, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020</wicri:regionArea><wicri:noRegion>Guanzhou 510020</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Li Zhi" sort="Wu, Li Zhi" uniqKey="Wu L" first="Li-Zhi" last="Wu">Li-Zhi Wu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Liu, Ran Yi" sort="Liu, Ran Yi" uniqKey="Liu R" first="Ran-Yi" last="Liu">Ran-Yi Liu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name><affiliation wicri:level="1"><nlm:aff id="aff1">Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Shao, Jing" sort="Shao, Jing" uniqKey="Shao J" first="Jing" last="Shao">Jing Shao</name><affiliation wicri:level="1"><nlm:aff id="aff4">Medical Research Center, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical Research Center, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020</wicri:regionArea><wicri:noRegion>Guanzhou 510020</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Bi Jun" sort="Huang, Bi Jun" uniqKey="Huang B" first="Bi-Jun" last="Huang">Bi-Jun Huang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Zeng, Yi Xin" sort="Zeng, Yi Xin" uniqKey="Zeng Y" first="Yi-Xin" last="Zeng">Yi-Xin Zeng</name><affiliation wicri:level="1"><nlm:aff id="aff1">Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Huang, Wenlin" sort="Huang, Wenlin" uniqKey="Huang W" first="Wenlin" last="Huang">Wenlin Huang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15784184</idno><idno type="pmc">7110803</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110803</idno><idno type="RBID">PMC:7110803</idno><idno type="doi">10.1016/j.micinf.2004.11.017</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">001290</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001290</idno><idno type="wicri:Area/Pmc/Curation">001290</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001290</idno><idno type="wicri:Area/Pmc/Checkpoint">001216</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001216</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome<sup><xref ref-type="fn" rid="d32e1261">☆</xref></sup></title><author><name sortKey="Huang, Jia Ling" sort="Huang, Jia Ling" uniqKey="Huang J" first="Jia-Ling" last="Huang">Jia-Ling Huang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Huang, Jian" sort="Huang, Jian" uniqKey="Huang J" first="Jian" last="Huang">Jian Huang</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of General Surgery, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of General Surgery, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020</wicri:regionArea><wicri:noRegion>Guanzhou 510020</wicri:noRegion></affiliation></author><author><name sortKey="Duan, Zhao Hui" sort="Duan, Zhao Hui" uniqKey="Duan Z" first="Zhao-Hui" last="Duan">Zhao-Hui Duan</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Clinical Test, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Test, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020</wicri:regionArea><wicri:noRegion>Guanzhou 510020</wicri:noRegion></affiliation></author><author><name sortKey="Wei, Jing" sort="Wei, Jing" uniqKey="Wei J" first="Jing" last="Wei">Jing Wei</name><affiliation wicri:level="1"><nlm:aff id="aff4">Medical Research Center, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical Research Center, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020</wicri:regionArea><wicri:noRegion>Guanzhou 510020</wicri:noRegion></affiliation></author><author><name sortKey="Min, Jun" sort="Min, Jun" uniqKey="Min J" first="Jun" last="Min">Jun Min</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of General Surgery, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of General Surgery, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020</wicri:regionArea><wicri:noRegion>Guanzhou 510020</wicri:noRegion></affiliation></author><author><name sortKey="Luo, Xiao Hong" sort="Luo, Xiao Hong" uniqKey="Luo X" first="Xiao-Hong" last="Luo">Xiao-Hong Luo</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Clinical Test, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Test, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020</wicri:regionArea><wicri:noRegion>Guanzhou 510020</wicri:noRegion></affiliation></author><author><name sortKey="Li, Jian Guo" sort="Li, Jian Guo" uniqKey="Li J" first="Jian-Guo" last="Li">Jian-Guo Li</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Respiratory Disease, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory Disease, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020</wicri:regionArea><wicri:noRegion>Guanzhou 510020</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Wei Ping" sort="Tan, Wei Ping" uniqKey="Tan W" first="Wei-Ping" last="Tan">Wei-Ping Tan</name><affiliation wicri:level="1"><nlm:aff id="aff6">Department of Pediatrics, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020</wicri:regionArea><wicri:noRegion>Guanzhou 510020</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Li Zhi" sort="Wu, Li Zhi" uniqKey="Wu L" first="Li-Zhi" last="Wu">Li-Zhi Wu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Liu, Ran Yi" sort="Liu, Ran Yi" uniqKey="Liu R" first="Ran-Yi" last="Liu">Ran-Yi Liu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name><affiliation wicri:level="1"><nlm:aff id="aff1">Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Shao, Jing" sort="Shao, Jing" uniqKey="Shao J" first="Jing" last="Shao">Jing Shao</name><affiliation wicri:level="1"><nlm:aff id="aff4">Medical Research Center, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical Research Center, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020</wicri:regionArea><wicri:noRegion>Guanzhou 510020</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Bi Jun" sort="Huang, Bi Jun" uniqKey="Huang B" first="Bi-Jun" last="Huang">Bi-Jun Huang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Zeng, Yi Xin" sort="Zeng, Yi Xin" uniqKey="Zeng Y" first="Yi-Xin" last="Zeng">Yi-Xin Zeng</name><affiliation wicri:level="1"><nlm:aff id="aff1">Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Huang, Wenlin" sort="Huang, Wenlin" uniqKey="Huang W" first="Wenlin" last="Huang">Wenlin Huang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author></analytic><series><title level="j">Microbes and Infection</title><idno type="ISSN">1286-4579</idno><idno type="eISSN">1769-714X</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The immune spectrum of severe acute respiratory syndrome (SARS) is poorly understood.</p><p>To define the dynamics of the immune spectrum in SARS, serum levels of cytokines, chemokines, immunoglobulins, complement and specific antibodies against SARS-associated coronavirus (SARS-CoV) were assayed by enzyme-linked immunosorbent assay (ELISA), and phenotypes of peripheral lymphocytes were analyzed by flow cytometry in 95 SARS-infected patients. Results showed that interleukin (IL)-10 and transforming growth factor β (TGF-β) were continuously up-regulated during the entirety of SARS. Regulated on activation normally T cell-expressed and secreted (RANTES) levels were decreased, while monocyte chemoattractant protein-1 (MCP-1) was elevated in acute patients. Immunoglobulins and complement were elevated during the first month of SARS. Both serum-positive rates and titers of specific IgM and IgG antibodies responding to SARS-CoV peaked at days 41–60 from the onset of SARS. CD4+ and CD8+ T lymphocytes decreased significantly in acute-phase. CD3+CD8+CD45RO+ T lymphocytes were decreased by 36.78% in the convalescent patients. Conclusion: SARS-CoV seemed to elicit effective humoral immunity but inhibited cellular immunity, especially CD8+ memory T lymphocytes over time. Prolonged overproduction of IL-10 and TGF-β may play an important role in the disease.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S. Gunther</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W. Preiser</name></author><author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S. van der Werf</name></author><author><name sortKey="Brodt, H R" uniqKey="Brodt H">H.R. Brodt</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S. Becker</name></author><author><name sortKey="Rabenau, H" uniqKey="Rabenau H">H. Rabenau</name></author><author><name sortKey="Panning, M" uniqKey="Panning M">M. Panning</name></author><author><name sortKey="Kolesnikova, L" uniqKey="Kolesnikova L">L. Kolesnikova</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name></author><author><name sortKey="Berger, A" uniqKey="Berger A">A. Berger</name></author><author><name sortKey="Burguiere, A M" uniqKey="Burguiere A">A.M. Burguiere</name></author><author><name sortKey="Cinatl, J" uniqKey="Cinatl J">J. Cinatl</name></author><author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M. Eickmann</name></author><author><name sortKey="Escriou, N" uniqKey="Escriou N">N. Escriou</name></author><author><name sortKey="Grywna, K" uniqKey="Grywna K">K. Grywna</name></author><author><name sortKey="Kramme, S" uniqKey="Kramme S">S. Kramme</name></author><author><name sortKey="Manuguerra, J C" uniqKey="Manuguerra J">J.C. Manuguerra</name></author><author><name sortKey="Muller, S" uniqKey="Muller S">S. Muller</name></author><author><name sortKey="Rickerts, V" uniqKey="Rickerts V">V. Rickerts</name></author><author><name sortKey="Sturmer, M" uniqKey="Sturmer M">M. Sturmer</name></author><author><name sortKey="Vieth, S" uniqKey="Vieth S">S. Vieth</name></author><author><name sortKey="Klenk, H D" uniqKey="Klenk H">H.D. Klenk</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author><author><name sortKey="Schmitz, H" uniqKey="Schmitz H">H. Schmitz</name></author><author><name sortKey="Doerr, H W" uniqKey="Doerr H">H.W. Doerr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ksiazek, T G" uniqKey="Ksiazek T">T.G. Ksiazek</name></author><author><name sortKey="Erdman, D" uniqKey="Erdman D">D. Erdman</name></author><author><name sortKey="Goldsmith, C S" uniqKey="Goldsmith C">C.S. Goldsmith</name></author><author><name sortKey="Zaki, S R" uniqKey="Zaki S">S.R. Zaki</name></author><author><name sortKey="Peret, T" uniqKey="Peret T">T. Peret</name></author><author><name sortKey="Emery, S" uniqKey="Emery S">S. Emery</name></author><author><name sortKey="Tong, S" uniqKey="Tong S">S. Tong</name></author><author><name sortKey="Urbani, C" uniqKey="Urbani C">C. Urbani</name></author><author><name sortKey="Comer, J A" uniqKey="Comer J">J.A. Comer</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W. Lim</name></author><author><name sortKey="Rollin, P E" uniqKey="Rollin P">P.E. Rollin</name></author><author><name sortKey="Dowell, S F" uniqKey="Dowell S">S.F. Dowell</name></author><author><name sortKey="Ling, A E" uniqKey="Ling A">A.E. Ling</name></author><author><name sortKey="Humphrey, C D" uniqKey="Humphrey C">C.D. Humphrey</name></author><author><name sortKey="Shieh, W J" uniqKey="Shieh W">W.J. Shieh</name></author><author><name sortKey="Guarner, J" uniqKey="Guarner J">J. Guarner</name></author><author><name sortKey="Paddock, C D" uniqKey="Paddock C">C.D. Paddock</name></author><author><name sortKey="Rota, P" uniqKey="Rota P">P. Rota</name></author><author><name sortKey="Fields, B" uniqKey="Fields B">B. Fields</name></author><author><name sortKey="De Risi, J" uniqKey="De Risi J">J. De Risi</name></author><author><name sortKey="Yang, J Y" uniqKey="Yang J">J.Y. Yang</name></author><author><name sortKey="Cox, N" uniqKey="Cox N">N. Cox</name></author><author><name sortKey="Hughes, J M" uniqKey="Hughes J">J.M. Hughes</name></author><author><name sortKey="Le Duc, J W" uniqKey="Le Duc J">J.W. Le Duc</name></author><author><name sortKey="Bellini, W J" uniqKey="Bellini W">W.J. Bellini</name></author><author><name sortKey="Anderson, L J" uniqKey="Anderson L">L.J. Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ding, Y" uniqKey="Ding Y">Y. Ding</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name></author><author><name sortKey="Shen, H" uniqKey="Shen H">H. Shen</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z. Li</name></author><author><name sortKey="Geng, J" uniqKey="Geng J">J. Geng</name></author><author><name sortKey="Han, H" uniqKey="Han H">H. Han</name></author><author><name sortKey="Cai, J" uniqKey="Cai J">J. Cai</name></author><author><name sortKey="Han, H" uniqKey="Han H">H. Han</name></author><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name></author><author><name sortKey="Kang, W" uniqKey="Kang W">W. Kang</name></author><author><name sortKey="Weng, D" uniqKey="Weng D">D. Weng</name></author><author><name sortKey="Liang, P" uniqKey="Liang P">P. Liang</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, G" uniqKey="Li G">G. Li</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name></author><author><name sortKey="Xu, A" uniqKey="Xu A">A. Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ooi, C G" uniqKey="Ooi C">C.G. Ooi</name></author><author><name sortKey="Khong, P L" uniqKey="Khong P">P.L. Khong</name></author><author><name sortKey="Ho, J C" uniqKey="Ho J">J.C. Ho</name></author><author><name sortKey="Lam, B" uniqKey="Lam B">B. Lam</name></author><author><name sortKey="Wong, W M" uniqKey="Wong W">W.M. Wong</name></author><author><name sortKey="Yiu, W C" uniqKey="Yiu W">W.C. Yiu</name></author><author><name sortKey="Wong, P C" uniqKey="Wong P">P.C. Wong</name></author><author><name sortKey="Wong, C F" uniqKey="Wong C">C.F. Wong</name></author><author><name sortKey="Lai, K N" uniqKey="Lai K">K.N. Lai</name></author><author><name sortKey="Tsang, K W" uniqKey="Tsang K">K.W. Tsang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, R S" uniqKey="Wong R">R.S. Wong</name></author><author><name sortKey="Wu, A" uniqKey="Wu A">A. Wu</name></author><author><name sortKey="To, K F" uniqKey="To K">K.F. To</name></author><author><name sortKey="Lee, N" uniqKey="Lee N">N. Lee</name></author><author><name sortKey="Lam, C W" uniqKey="Lam C">C.W. Lam</name></author><author><name sortKey="Wong, C K" uniqKey="Wong C">C.K. Wong</name></author><author><name sortKey="Chan, P K" uniqKey="Chan P">P.K. Chan</name></author><author><name sortKey="Ng, M H" uniqKey="Ng M">M.H. Ng</name></author><author><name sortKey="Yu, L M" uniqKey="Yu L">L.M. Yu</name></author><author><name sortKey="Hui, D S" uniqKey="Hui D">D.S. Hui</name></author><author><name sortKey="Tam, J S" uniqKey="Tam J">J.S. Tam</name></author><author><name sortKey="Cheng, G" uniqKey="Cheng G">G. Cheng</name></author><author><name sortKey="Sung, J J" uniqKey="Sung J">J.J. Sung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cui, W" uniqKey="Cui W">W. Cui</name></author><author><name sortKey="Fan, Y" uniqKey="Fan Y">Y. Fan</name></author><author><name sortKey="Wu, W" uniqKey="Wu W">W. Wu</name></author><author><name sortKey="Zhang, F" uniqKey="Zhang F">F. Zhang</name></author><author><name sortKey="Wang, J Y" uniqKey="Wang J">J.Y. Wang</name></author><author><name sortKey="Ni, A P" uniqKey="Ni A">A.P. Ni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name></author><author><name sortKey="Jia, W D" uniqKey="Jia W">W.D. Jia</name></author><author><name sortKey="Xu, A" uniqKey="Xu A">A. Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Z" uniqKey="Li Z">Z. Li</name></author><author><name sortKey="Guo, X" uniqKey="Guo X">X. Guo</name></author><author><name sortKey="Hao, W" uniqKey="Hao W">W. Hao</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y. Wu</name></author><author><name sortKey="Ji, Y" uniqKey="Ji Y">Y. Ji</name></author><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y. Zhao</name></author><author><name sortKey="Liu, F" uniqKey="Liu F">F. Liu</name></author><author><name sortKey="Xie, X" uniqKey="Xie X">X. Xie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nicholls, J M" uniqKey="Nicholls J">J.M. Nicholls</name></author><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name></author><author><name sortKey="Lee K, C" uniqKey="Lee K C">C. Lee K</name></author><author><name sortKey="Ng, W F" uniqKey="Ng W">W.F. Ng</name></author><author><name sortKey="Lai, S T" uniqKey="Lai S">S.T. Lai</name></author><author><name sortKey="Leung, C Y" uniqKey="Leung C">C.Y. Leung</name></author><author><name sortKey="Chu, C M" uniqKey="Chu C">C.M. Chu</name></author><author><name sortKey="Hui, P K" uniqKey="Hui P">P.K. Hui</name></author><author><name sortKey="Mak, K L" uniqKey="Mak K">K.L. Mak</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W. Lim</name></author><author><name sortKey="Yan, K W" uniqKey="Yan K">K.W. Yan</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Tsang, N C" uniqKey="Tsang N">N.C. Tsang</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, C K" uniqKey="Wong C">C.K. Wong</name></author><author><name sortKey="Lam, C W" uniqKey="Lam C">C.W. Lam</name></author><author><name sortKey="Wu, A K" uniqKey="Wu A">A.K. Wu</name></author><author><name sortKey="Ip, W K" uniqKey="Ip W">W.K. Ip</name></author><author><name sortKey="Lee, N L" uniqKey="Lee N">N.L. Lee</name></author><author><name sortKey="Chan, I H" uniqKey="Chan I">I.H. Chan</name></author><author><name sortKey="Lit, L C" uniqKey="Lit L">L.C. Lit</name></author><author><name sortKey="Hui, D S" uniqKey="Hui D">D.S. Hui</name></author><author><name sortKey="Chan, M H" uniqKey="Chan M">M.H. Chan</name></author><author><name sortKey="Chung, S S" uniqKey="Chung S">S.S. Chung</name></author><author><name sortKey="Sung, J J" uniqKey="Sung J">J.J. Sung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ning, Q" uniqKey="Ning Q">Q. Ning</name></author><author><name sortKey="Brown, D" uniqKey="Brown D">D. Brown</name></author><author><name sortKey="Parodo, J" uniqKey="Parodo J">J. Parodo</name></author><author><name sortKey="Cattral, M" uniqKey="Cattral M">M. Cattral</name></author><author><name sortKey="Gorczynski, R" uniqKey="Gorczynski R">R. Gorczynski</name></author><author><name sortKey="Cole, E" uniqKey="Cole E">E. Cole</name></author><author><name sortKey="Fung, L" uniqKey="Fung L">L. Fung</name></author><author><name sortKey="Ding, J W" uniqKey="Ding J">J.W. Ding</name></author><author><name sortKey="Liu, M F" uniqKey="Liu M">M.F. Liu</name></author><author><name sortKey="Rotstein, O" uniqKey="Rotstein O">O. Rotstein</name></author><author><name sortKey="Phillips, M J" uniqKey="Phillips M">M.J. Phillips</name></author><author><name sortKey="Levy, G" uniqKey="Levy G">G. Levy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palmer, G H" uniqKey="Palmer G">G.H. Palmer</name></author><author><name sortKey="Machado, T" uniqKey="Machado T">T. Machado</name></author><author><name sortKey="Fernandez, P" uniqKey="Fernandez P">P. Fernandez</name></author><author><name sortKey="Heussler, V" uniqKey="Heussler V">V. Heussler</name></author><author><name sortKey="Perinat, T" uniqKey="Perinat T">T. Perinat</name></author><author><name sortKey="Dobbelaere, D A" uniqKey="Dobbelaere D">D.A. Dobbelaere</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, R E" uniqKey="Lee R">R.E. Lee</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Karupiah, G" uniqKey="Karupiah G">G. Karupiah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perlman, S" uniqKey="Perlman S">S. Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glass, W G" uniqKey="Glass W">W.G. Glass</name></author><author><name sortKey="Rosenberg, H F" uniqKey="Rosenberg H">H.F. Rosenberg</name></author><author><name sortKey="Murphy, P M" uniqKey="Murphy P">P.M. Murphy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Annunziato, F" uniqKey="Annunziato F">F. Annunziato</name></author><author><name sortKey="Galli, G" uniqKey="Galli G">G. Galli</name></author><author><name sortKey="Nappi, F" uniqKey="Nappi F">F. Nappi</name></author><author><name sortKey="Cosmi, L" uniqKey="Cosmi L">L. Cosmi</name></author><author><name sortKey="Manetti, R" uniqKey="Manetti R">R. Manetti</name></author><author><name sortKey="Maggi, E" uniqKey="Maggi E">E. Maggi</name></author><author><name sortKey="Ensoli, B" uniqKey="Ensoli B">B. Ensoli</name></author><author><name sortKey="Romagnani, S" uniqKey="Romagnani S">S. Romagnani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thompson, B T" uniqKey="Thompson B">B.T. Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hong, N" uniqKey="Hong N">N. Hong</name></author><author><name sortKey="Du, X K" uniqKey="Du X">X.K. Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cyranoski, D" uniqKey="Cyranoski D">D. Cyranoski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, G W" uniqKey="Li G">G.W. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Panesar, N S" uniqKey="Panesar N">N.S. Panesar</name></author><author><name sortKey="Lam, C W K" uniqKey="Lam C">C.W.K. Lam</name></author><author><name sortKey="Chan, M H M" uniqKey="Chan M">M.H.M. Chan</name></author><author><name sortKey="Wong, C K" uniqKey="Wong C">C.K. Wong</name></author><author><name sortKey="Sung, J J Y" uniqKey="Sung J">J.J.Y. Sung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oba, Y" uniqKey="Oba Y">Y. Oba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Panesar, N S" uniqKey="Panesar N">N.S. Panesar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Multz, A S" uniqKey="Multz A">A.S. Multz</name></author><author><name sortKey="Cohen, R" uniqKey="Cohen R">R. Cohen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, X M" uniqKey="Wu X">X.M. Wu</name></author><author><name sortKey="Wang, X Y" uniqKey="Wang X">X.Y. Wang</name></author><author><name sortKey="Chen, P H" uniqKey="Chen P">P.H. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kottilil, S" uniqKey="Kottilil S">S. Kottilil</name></author><author><name sortKey="Chun, T W" uniqKey="Chun T">T.W. Chun</name></author><author><name sortKey="Moir, S" uniqKey="Moir S">S. Moir</name></author><author><name sortKey="Liu, S" uniqKey="Liu S">S. Liu</name></author><author><name sortKey="Mclaughlin, M" uniqKey="Mclaughlin M">M. McLaughlin</name></author><author><name sortKey="Hallahan, C W" uniqKey="Hallahan C">C.W. Hallahan</name></author><author><name sortKey="Maldarelli, F" uniqKey="Maldarelli F">F. Maldarelli</name></author><author><name sortKey="Corey, L" uniqKey="Corey L">L. Corey</name></author><author><name sortKey="Fauci, A S" uniqKey="Fauci A">A.S. Fauci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hackney, K" uniqKey="Hackney K">K. Hackney</name></author><author><name sortKey="Cavanagh, D" uniqKey="Cavanagh D">D. Cavanagh</name></author><author><name sortKey="Kaiser, P" uniqKey="Kaiser P">P. Kaiser</name></author><author><name sortKey="Britton, P" uniqKey="Britton P">P. Britton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dunne, P J" uniqKey="Dunne P">P.J. Dunne</name></author><author><name sortKey="Faint, J M" uniqKey="Faint J">J.M. Faint</name></author><author><name sortKey="Gudgeon, N H" uniqKey="Gudgeon N">N.H. Gudgeon</name></author><author><name sortKey="Fletcher, J M" uniqKey="Fletcher J">J.M. Fletcher</name></author><author><name sortKey="Plunkett, F J" uniqKey="Plunkett F">F.J. Plunkett</name></author><author><name sortKey="Soares, M V" uniqKey="Soares M">M.V. Soares</name></author><author><name sortKey="Hislop, A D" uniqKey="Hislop A">A.D. Hislop</name></author><author><name sortKey="Annels, N E" uniqKey="Annels N">N.E. Annels</name></author><author><name sortKey="Rickinson, A B" uniqKey="Rickinson A">A.B. Rickinson</name></author><author><name sortKey="Salmon, M" uniqKey="Salmon M">M. Salmon</name></author><author><name sortKey="Akbar, A N" uniqKey="Akbar A">A.N. Akbar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nijhuis, E W" uniqKey="Nijhuis E">E.W. Nijhuis</name></author><author><name sortKey="Hinloopen, B" uniqKey="Hinloopen B">B. Hinloopen</name></author><author><name sortKey="Van Lier, R A" uniqKey="Van Lier R">R.A. van Lier</name></author><author><name sortKey="Nagelkerken, L" uniqKey="Nagelkerken L">L. Nagelkerken</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mor, F" uniqKey="Mor F">F. Mor</name></author><author><name sortKey="Cohen, I R" uniqKey="Cohen I">I.R. Cohen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhong, Y F" uniqKey="Zhong Y">Y.F. Zhong</name></author><author><name sortKey="Gao, X M" uniqKey="Gao X">X.M. Gao</name></author><author><name sortKey="Wang, S L" uniqKey="Wang S">S.L. Wang</name></author><author><name sortKey="Xie, Z G" uniqKey="Xie Z">Z.G. Xie</name></author><author><name sortKey="Ma, Y" uniqKey="Ma Y">Y. Ma</name></author><author><name sortKey="Fang, W G" uniqKey="Fang W">W.G. Fang</name></author><author><name sortKey="Zou, W Z" uniqKey="Zou W">W.Z. Zou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bellinghausen, I" uniqKey="Bellinghausen I">I. Bellinghausen</name></author><author><name sortKey="Brand, U" uniqKey="Brand U">U. Brand</name></author><author><name sortKey="Steinbrink, K" uniqKey="Steinbrink K">K. Steinbrink</name></author><author><name sortKey="Enk, A H" uniqKey="Enk A">A.H. Enk</name></author><author><name sortKey="Knop, J" uniqKey="Knop J">J. Knop</name></author><author><name sortKey="Saloga, J" uniqKey="Saloga J">J. Saloga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tripp, R A" uniqKey="Tripp R">R.A. Tripp</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Booth, C M" uniqKey="Booth C">C.M. Booth</name></author><author><name sortKey="Matukas, L M" uniqKey="Matukas L">L.M. Matukas</name></author><author><name sortKey="Tomlinson, G A" uniqKey="Tomlinson G">G.A. Tomlinson</name></author><author><name sortKey="Rachlis, A R" uniqKey="Rachlis A">A.R. Rachlis</name></author><author><name sortKey="Rose, D B" uniqKey="Rose D">D.B. Rose</name></author><author><name sortKey="Dwosh, H A" uniqKey="Dwosh H">H.A. Dwosh</name></author><author><name sortKey="Walmsley, S L" uniqKey="Walmsley S">S.L. Walmsley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seo, S H" uniqKey="Seo S">S.H. Seo</name></author><author><name sortKey="Pei, J" uniqKey="Pei J">J. Pei</name></author><author><name sortKey="Briles, W E" uniqKey="Briles W">W.E. Briles</name></author><author><name sortKey="Dzielawa, J" uniqKey="Dzielawa J">J. Dzielawa</name></author><author><name sortKey="Collisson, E W" uniqKey="Collisson E">E.W. Collisson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Swain, S L" uniqKey="Swain S">S.L. Swain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Z Y" uniqKey="Yang Z">Z.Y. Yang</name></author><author><name sortKey="Kong, W P" uniqKey="Kong W">W.P. Kong</name></author><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y. Huang</name></author><author><name sortKey="Roberts, A" uniqKey="Roberts A">A. Roberts</name></author><author><name sortKey="Murphy, B R" uniqKey="Murphy B">B.R. Murphy</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. Subbarao</name></author><author><name sortKey="Nabel, G J" uniqKey="Nabel G">G.J. Nabel</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Microbes Infect</journal-id><journal-id journal-id-type="iso-abbrev">Microbes Infect</journal-id><journal-title-group><journal-title>Microbes and Infection</journal-title></journal-title-group><issn pub-type="ppub">1286-4579</issn><issn pub-type="epub">1769-714X</issn><publisher><publisher-name>Elsevier SAS.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">15784184</article-id><article-id pub-id-type="pmc">7110803</article-id><article-id pub-id-type="publisher-id">S1286-4579(05)00030-4</article-id><article-id pub-id-type="doi">10.1016/j.micinf.2004.11.017</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome<sup><xref ref-type="fn" rid="d32e1261">☆</xref></sup></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Jia-Ling</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Jian</given-names></name><xref rid="aff2" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Duan</surname><given-names>Zhao-Hui</given-names></name><xref rid="aff3" ref-type="aff">c</xref></contrib><contrib contrib-type="author"><name><surname>Wei</surname><given-names>Jing</given-names></name><xref rid="aff4" ref-type="aff">d</xref></contrib><contrib contrib-type="author"><name><surname>Min</surname><given-names>Jun</given-names></name><xref rid="aff2" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Luo</surname><given-names>Xiao-Hong</given-names></name><xref rid="aff3" ref-type="aff">c</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Jian-Guo</given-names></name><xref rid="aff5" ref-type="aff">e</xref></contrib><contrib contrib-type="author"><name><surname>Tan</surname><given-names>Wei-Ping</given-names></name><xref rid="aff6" ref-type="aff">f</xref></contrib><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Li-Zhi</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Ran-Yi</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Yan</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Shao</surname><given-names>Jing</given-names></name><xref rid="aff4" ref-type="aff">d</xref></contrib><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Bi-Jun</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Zeng</surname><given-names>Yi-Xin</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Wenlin</given-names></name><email>wl_huang@hotmail.com</email><xref rid="aff1" ref-type="aff">a</xref><xref rid="cor1" ref-type="corresp">*</xref></contrib></contrib-group><aff id="aff1"><label>a</label>Cancer Institute, Cancer Center and World Health Organization (WHO) Cooperative Cancer Research Center, Cancer Center of Sun Yat-sen University, No. 651 Dongfeng Road East, Guangzhou 510060, China</aff><aff id="aff2"><label>b</label>Department of General Surgery, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020, China</aff><aff id="aff3"><label>c</label>Department of Clinical Test, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020, China</aff><aff id="aff4"><label>d</label>Medical Research Center, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020, China</aff><aff id="aff5"><label>e</label>Department of Respiratory Disease, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020, China</aff><aff id="aff6"><label>f</label>Department of Pediatrics, The Second Affiliated Hospital of Sun Yat-sen University, No. 107 Yanjiang Road, Guanzhou 510020, China</aff><author-notes><corresp id="cor1"><label>*</label>Corresponding author. Tel./fax: +86 20 873 43146. <email>wl_huang@hotmail.com</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>24</day><month>2</month><year>2005</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>3</month><year>2005</year></pub-date><pub-date pub-type="epub"><day>24</day><month>2</month><year>2005</year></pub-date><volume>7</volume><issue>3</issue><fpage>427</fpage><lpage>436</lpage><history><date date-type="received"><day>19</day><month>10</month><year>2004</year></date><date date-type="accepted"><day>25</day><month>11</month><year>2004</year></date></history><permissions><copyright-statement>Copyright © 2005 Elsevier SAS. All rights reserved.</copyright-statement><copyright-year>2005</copyright-year><copyright-holder>Elsevier SAS</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract><p>The immune spectrum of severe acute respiratory syndrome (SARS) is poorly understood.</p><p>To define the dynamics of the immune spectrum in SARS, serum levels of cytokines, chemokines, immunoglobulins, complement and specific antibodies against SARS-associated coronavirus (SARS-CoV) were assayed by enzyme-linked immunosorbent assay (ELISA), and phenotypes of peripheral lymphocytes were analyzed by flow cytometry in 95 SARS-infected patients. Results showed that interleukin (IL)-10 and transforming growth factor β (TGF-β) were continuously up-regulated during the entirety of SARS. Regulated on activation normally T cell-expressed and secreted (RANTES) levels were decreased, while monocyte chemoattractant protein-1 (MCP-1) was elevated in acute patients. Immunoglobulins and complement were elevated during the first month of SARS. Both serum-positive rates and titers of specific IgM and IgG antibodies responding to SARS-CoV peaked at days 41–60 from the onset of SARS. CD4+ and CD8+ T lymphocytes decreased significantly in acute-phase. CD3+CD8+CD45RO+ T lymphocytes were decreased by 36.78% in the convalescent patients. Conclusion: SARS-CoV seemed to elicit effective humoral immunity but inhibited cellular immunity, especially CD8+ memory T lymphocytes over time. Prolonged overproduction of IL-10 and TGF-β may play an important role in the disease.</p></abstract><kwd-group><title>Keywords</title><kwd>Severe acute respiratory syndrome</kwd><kwd>Immune monitoring</kwd><kwd>Immune system</kwd></kwd-group><kwd-group><title>Abbreviations</title><kwd>ALT, aminotransferase</kwd><kwd>ANOVA, analysis of variance</kwd><kwd>AST, aspartate aminotransferase</kwd><kwd>C, complement</kwd><kwd>CoV, coronavirus</kwd><kwd>ctr, control</kwd><kwd>ELISA, enzyme-linked immunosorbent assay</kwd><kwd>FBS, fetal bovine serum</kwd><kwd>IFN-γ, interferon γ</kwd><kwd>Ig, immunoglobulin</kwd><kwd>IL, interleukin</kwd><kwd>MCP-1, monocyte chemoattractant protein-1</kwd><kwd>NF-κB, nuclear factor κB</kwd><kwd>PBMC, peripheral blood mononuclear cell</kwd><kwd>RANTES, regulated on activation normally T cell-expressed and secreted</kwd><kwd>SARS, severe acute respiratory syndrome</kwd><kwd>SARS-CoV, SARS-associated coronavirus</kwd><kwd>S.D., standard deviation</kwd><kwd>TGF, transforming growth factor</kwd><kwd>TNF, tumor necrosis factor</kwd></kwd-group></article-meta><notes><p>Dr. Jia-Ling Huang, Jian Huang and Zhao-Hui Duan contributed equally to this article</p></notes></front></pmc><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Guangdong</li></region><settlement><li>Jiangmen</li></settlement></list><tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Huang, Jia Ling" sort="Huang, Jia Ling" uniqKey="Huang J" first="Jia-Ling" last="Huang">Jia-Ling Huang</name></region><name sortKey="Duan, Zhao Hui" sort="Duan, Zhao Hui" uniqKey="Duan Z" first="Zhao-Hui" last="Duan">Zhao-Hui Duan</name><name sortKey="Huang, Bi Jun" sort="Huang, Bi Jun" uniqKey="Huang B" first="Bi-Jun" last="Huang">Bi-Jun Huang</name><name sortKey="Huang, Jian" sort="Huang, Jian" uniqKey="Huang J" first="Jian" last="Huang">Jian Huang</name><name sortKey="Huang, Wenlin" sort="Huang, Wenlin" uniqKey="Huang W" first="Wenlin" last="Huang">Wenlin Huang</name><name sortKey="Li, Jian Guo" sort="Li, Jian Guo" uniqKey="Li J" first="Jian-Guo" last="Li">Jian-Guo Li</name><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name><name sortKey="Liu, Ran Yi" sort="Liu, Ran Yi" uniqKey="Liu R" first="Ran-Yi" last="Liu">Ran-Yi Liu</name><name sortKey="Luo, Xiao Hong" sort="Luo, Xiao Hong" uniqKey="Luo X" first="Xiao-Hong" last="Luo">Xiao-Hong Luo</name><name sortKey="Min, Jun" sort="Min, Jun" uniqKey="Min J" first="Jun" last="Min">Jun Min</name><name sortKey="Shao, Jing" sort="Shao, Jing" uniqKey="Shao J" first="Jing" last="Shao">Jing Shao</name><name sortKey="Tan, Wei Ping" sort="Tan, Wei Ping" uniqKey="Tan W" first="Wei-Ping" last="Tan">Wei-Ping Tan</name><name sortKey="Wei, Jing" sort="Wei, Jing" uniqKey="Wei J" first="Jing" last="Wei">Jing Wei</name><name sortKey="Wu, Li Zhi" sort="Wu, Li Zhi" uniqKey="Wu L" first="Li-Zhi" last="Wu">Li-Zhi Wu</name><name sortKey="Zeng, Yi Xin" sort="Zeng, Yi Xin" uniqKey="Zeng Y" first="Yi-Xin" last="Zeng">Yi-Xin Zeng</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001216 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 001216 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Pmc
|étape= Checkpoint
|type= RBID
|clé= PMC:7110803
|texte= Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome☆
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:15784184" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |